Addiction and Polydrug Use
Mixing multiple substances is known as “polydrug use” or “polysubstance use.” Users often combine different drugs to achieve specific effects, like mixing cocaine with alcohol to counteract drowsiness. This can be extremely dangerous, as various combinations may lead to unpredictable reactions, addiction, overdose, or even death, according to a University of Michigan study.
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What Is Polydrug Use?
Polydrug use, also known as polysubstance use, describes when a person takes multiple substances (either together or one after the other) for recreational purposes. These combinations can include the use of alcohol, prescription drugs, and/or illicit drugs.
A typical example of polysubstance use is taking a pill (whether prescribed, recreational, or over-the-counter) and washing it down with a beer or another alcoholic beverage.
Some other common forms of polydrug use include:
- Mixing drugs, such as lacing one drug with another
- Using multiple substances to amplify their effects
- Using one substance to counter the effects of another substance
- Using a different substance when the substance you want is no longer available
While polydrug use was at one time considered its diagnosis in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), it now falls under the substance use disorder category.
Polysubstance Addiction
When someone takes multiple substances either at once or concurrently, they increase the risk of becoming addicted to all the substances they are taking. Since addiction changes the overall chemistry of the brain, once the brain determines that it needs multiple substances, it will crave them.
People suffering from polysubstance addiction might experience their cravings for each drug differently. For example, some people crave nicotine only when drinking alcohol.
A consequence of polysubstance addiction is the increased risk of significant health issues. Each substance has its own set of side effects, and mixing multiple substances can have an adverse reaction on the body, resulting in potentially deadly health problems.
What Is Substance Use Disorder?
Substance use disorder is another term for addiction. Someone suffering from a substance use disorder can’t function properly without having said substances in their system.
They also continue to use and abuse this substance even when it negatively affects their health, relationships, finances, or legal standing.
Someone suffering from a substance use disorder might branch out and turn to other substances to find new ways of achieving their desired effect. Their addiction to a specific substance might be so great that they must mix in something else to get the “high” they want.
Dangers of Polydrug Use
Mixing different types of drugs can not only increase the chances of the development of an addiction, but it can also cause serious physical and mental health complications.
Some of the reasons why a person might decide to mix substances include:
- To counter the effects of another substance
- To enhance the “high”
- When their substance of choice is not available
- When they are already under the influence of one substance and take another without thinking about it
Risks of Combining Drugs
Whether it’s something that is medically prescribed, purchased over the counter, or obtained illegally, all substances have side effects. Mixing substances can be dangerous and lead to significant mental and physical ailments.
Some of the side effects associated with polysubstance use and abuse include:
- Depression
- Anxiety
- Hallucinations
- Brain damage
- Organ failure
- Stroke
- Heart attack
- Rapid or slow heart rate
- Breathing issues
- Loss of consciousness
- Respiratory failure
- Uncontrollable muscle spasms
- Memory loss
- Fatal overdose
Opioid overdose is becoming a bigger concern, as many drug users are unaware that opioids (like fentanyl) have been added to their other illicit drugs. Cocaine, MDMA, and crystal meth are among the most common drugs often laced with opiates—in many cases, unbeknownst to the user.
What Drugs Are Commonly Combined?
While mixing any combination of substances is considered polysubstance use, certain mixtures are more common than others. Stimulants, depressants, over-the-counter and prescription medications, and alcohol are all substances that people commonly combine.
Some combinations have achieved notoriety in pop culture, appearing in songs, movies, etc., due to their popularity in the club-going and polydrug use scenes. One popular combination, for example, is known as a “speedball,” which combines heroin and cocaine.
Stimulant Polydrug Use
Stimulants (such as cocaine, methamphetamines, or ecstasy/MDMA) can lead to increased heart rate and blood pressure, often to dangerous levels.
Mixing stimulants can lead to:
- Heart attack
- Stroke
- Liver damage
- Brain damage
- Seizures
- Nausea
- Vomiting
- Chest pain
- Increased body temperature
- Psychosis
- Anxiety
- Panic attacks
Depressant Polydrug Use
Depressants (like cannabis, alcohol, or opiates) slow down the body and the brain and reduce a person’s breathing.
Mixing depressants can slow the central nervous system down to dangerous levels, which can lead to:
- Brain damage
- Organ damage and failure
- Unconsciousness
- Weak pulse
- Altered mental state
- Confusion
- Increased risk of injury
- Impaired judgment
- Lack of coordination
- Vomiting
- Memory loss
- Irregular breathing
Mixing Stimulants and Depressants
While some people might think that mixing stimulants and depressants might counter one or the other or even cancel each other out, that is not the case. Combining the two can put extra stress on the body and potentially lead to overdose and death.
The additional strain that combining stimulants and depressants place on the body can lead to major medical complications such as:
- Respiratory issues, including infections
- Heart problems
- Kidney failure
- Dehydration
- Overheating
Mixing Drugs (Any Type) and Alcohol
Alcohol is a depressant and shares many similar effects that depressant drugs do.
As a result, mixing drugs with alcohol can lead to the following issues:
- Drowsiness
- Lightheadedness
- Difficulty concentrating
- Inability to perform basic tasks
- Increased risk of injury
- Liver damage
- Seizures
- Compromised immune system
Polydrug Use Statistics
According to a June 2020 study, 35 million people in the U.S. meet the criteria for a substance use disorder. Additionally—
- Of the 35 million people who qualified for a substance use disorder, roughly 11% also had a polydrug use disorder involving alcohol
- According to the CDC, in 2019, 50% of all drug overdose deaths involved more than one drug
- Alcohol is the most common substance involved with polysubstance use
- According to a 2014 SAMHSA report, nearly 1 million ER visits from 2005-2011 involved a combination of benzodiazepines and another illicit substance
Polydrug Use in Young People
When it comes to experimenting with drug use, including mixing substances, teens and young adults do so at a higher rate than any other age demographic.
A study by the RAND Research Institute in Los Angeles found that 29% of California high school seniors engaged in polydrug use in the past 12 months.
The same study found that the main contributing factors for polysubstance use in adolescents are:
- Peer pressure
- Pro-drug environment
- Rebelliousness
- Family issues
Additionally, teenage boys are far more likely to engage in polydrug use than teen girls.
According to the National Institute on Drug Abuse (NIDA), polydrug use is also common in the “club scene,” which became popularized in the 1990s at raves and similar settings.
Polydrug use among club attendees typically involves some combination of psychoactive substances, the most popular being:
- Alcohol
- MDMA (ecstasy)
- Cocaine
- Ketamine
- Crystal meth
- LSD (acid)
- GHB
Getting Help for Polydrug Abuse
When not appropriately addressed, polysubstance abuse and addiction can be deadly. If you or a loved one is struggling with polydrug abuse and addiction, medical intervention is usually necessary to help you achieve sobriety and regain control of your life.
Medical Detox
As with any substance of abuse, the first step in the treatment process is to undergo detox treatment. Detoxing rids the body of harmful substances so that the body and brain can begin healing.
Due to the nature of detoxing and the withdrawal symptoms associated with it, the detox process should occur under the care and supervision of trained medical professionals.
In many cases, an individual can still undergo a supervised detox at the outpatient level but will still benefit from the overall supervision of a medical professional.
Self-detox can be dangerous and even life-threatening and should not occur without speaking to a doctor or healthcare professional first.
Addiction Treatment Programs
Once detox has been completed, the next step is to enter into a substance abuse treatment program. Based on your needs and the advice of your treatment professional, you will likely do either inpatient or outpatient treatment.
Treatment for polydrug use and addiction focuses most on psychotherapy, especially styles like Cognitive Behavioral Therapy.
Psychotherapy helps identify the initial cause or causes of the development of the addiction and teaches better ways to deal with triggers in the future that don’t involve drugs or alcohol.
Medication-assisted treatment might also be used depending on the severity of the addiction and the substances used. Certain medications can help with withdrawal symptoms, especially during detox, including buprenorphine, methadone, and naltrexone.
Support Groups
Support groups can provide a robust support system that many in recovery need during and after treatment. Peer-based recovery groups such as Alcoholics Anonymous, Narcotics Anonymous, and SMART Recovery are all designed to provide a safe and supportive environment for those in recovery.
Find Help for Substance Use Disorder
Whether it is one or multiple substances, it is essential to remember that treatment options are available for those suffering from addiction.
Call the SAMHSA helpline at 1-800-662-4357 or visit their online program locator to find polydrug treatment options in your area.
Frequently Asked Questions About Polydrug Use
What does polydrug abuse mean?
Polydrug abuse, also known as polysubstance abuse, refers to using two or more substances at the same time or within a short period to intensify their effects. This behavior can significantly increase the risk of dangerous side effects, overdose, and long-term health issues.
Does smoking weed and drinking alcohol count as polysubstance abuse?
Yes, using marijuana and alcohol together is considered polysubstance abuse. Even though these substances are common and legal in some places, combining them can lead to impaired judgment, increased sedation, and a higher risk of accidents or harmful behaviors.
What is speedballing?
Speedballing refers to the dangerous practice of combining a stimulant (like cocaine or methamphetamine) with a depressant (like heroin or fentanyl). The stimulant increases energy and alertness, while the depressant slows the body down.
This combination is particularly risky because it can mask overdose warning signs, leading to potentially fatal outcomes.
What are the three most common types of polysubstance abuse?
The three most common types of polysubstance abuse include—
- Alcohol and cocaine: A combination often used to enhance social interactions and prolong intoxication.
- Opioids and benzodiazepines: Used together to increase sedative effects but are highly dangerous due to the risk of respiratory depression.
- Alcohol and prescription stimulants: Often combined to balance out the sedating effects of alcohol with increased alertness from stimulants.
What are some examples of polydrug use?
Examples of polydrug use include—
- Taking prescription painkillers with alcohol.
- Using heroin alongside benzodiazepines like Xanax.
- Smoking marijuana while using hallucinogens like LSD.
Can you combine drugs if they’re the same type?
Even if drugs are the same type, combining them can still be dangerous. For example, taking multiple sedatives, like sleeping pills and alcohol, can dangerously slow down your breathing and heart rate. Similarly, combining multiple stimulants can increase your risk of heart attack, seizures, and paranoia.
Can someone become addicted to more than one drug?
Yes, it is possible to become addicted to multiple drugs at the same time. This is known as cross-addiction or multiple substance dependence. People who use multiple substances often develop a dependence on more than one, which can make treatment more complex but still entirely possible with the right support and care.
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